Musculoskeletal Bibliography
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| title | Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points |
| type | article in a journal |
| link | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WB6-4RFH4P9 [snip!] open in  this window or  new window |
| note | This important paper demonstrates that the biochemical milieu of trigger points is strongly acidic and full of large quantities of pain-causing metabolites: powerful evidence that the energy crisis theory of trigger point formation and perpetuation is correct. It’s an improvement on an earlier paper from 2005 (Shah), with improved methods. It is cogently summarized by Simons, and in my short article Toxic Muscle Knots. |
| authors | Jay P Shah, Jerome V Danoff, Mehul J Desai, Sagar Parikh, Lynn Y Nakamura, Terry M Phillips, and Lynn H Gerber |
| keywords | myofascial pain syndrome, pain, low back pain, neck pain |
| journal | Archives of Physical Medicine & Rehabilitation |
| year | 2008 |
| volume | 89 |
| number | 1 |
| pages | 16–23 |
| abstract | OBJECTIVES: To investigate the biochemical milieu of the upper trapezius muscle in subjects with active, latent, or absent myofascial trigger points (MTPs) and to contrast this with that of the noninvolved gastrocnemius muscle. DESIGN: We used a microanalytic technique, including needle insertions at standardized locations in subjects identified as active (having neck pain and MTP), latent (no neck pain but with MTP), or normal (no neck pain, no MTP). We followed a predetermined sampling schedule; first in the trapezius muscle and then in normal gastrocnemius muscle, to measure pH, bradykinin, substance P, calcitonin gene-related peptide, tumor necrosis factor alpha, interleukin 1beta (IL-1beta), IL-6, IL-8, serotonin, and norepinephrine, using immunocapillary electrophoresis and capillary electrochromatography. Pressure algometry was obtained. We compared analyte concentrations among groups with 2-way repeated-measures analysis of variance. SETTING: A biomedical research facility. PARTICIPANTS: Nine healthy volunteer subjects. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Preselected analyte concentrations. RESULTS: Within the trapezius muscle, concentrations for all analytes were higher in active subjects than in latent or normal subjects (P<.002); pH was lower (P<.03). At needle insertion, analyte concentrations in the trapezius for the active group were always higher (pH not different) than concentrations in the gastrocnemius muscle. At all times within the gastrocnemius, the active group had higher concentrations of all analytes than did subjects in the latent and normal groups (P<.05); pH was lower (P<.01). CONCLUSIONS: We have shown the feasibility of continuous, in vivo recovery of small molecules from soft tissue without harmful effects. Subjects with active MTPs in the trapezius muscle have a biochemical milieu of selected inflammatory mediators, neuropeptides, cytokines, and catecholamines different from subjects with latent or absent MTPs in their trapezius. These concentrations also differ quantitatively from a remote, uninvolved site in the gastrocnemius muscle. The milieu of the gastrocnemius in subjects with active MTPs in the trapezius differs from subjects without active MTPs.
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| 3 related items | These 3 items have been specifically marked as related to this item. “An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle,” an article in Journal of Applied Physiology, 2005. “New Views of Myofascial Trigger Points: Etiology and Diagnosis,” an article in Archives of Physical Medicine & Rehabilitation, 2008. SY Toxic Muscle Knots — New research confirms that muscle knots (myofascial trigger points) really are quagmires of toxic, irritating molecules |
| 6 articles citing this record | These 6 articles on SaveYourself.ca cite this item as a source: SY Save Yourself from Trigger Points & Myofascial Pain Syndrome! SY Save Yourself from Plantar Fasciitis! SY Save Yourself from Shin Splints! SY Toxic Muscle Knots SY Into the Fire SY Should You Drink Water After Massage? |
